He picked up the Nobel Peace Prize on behalf of his organisation less than three years ago. But it was pride before the fall. Now, I say he should go.
Go to a psychotherapist and get some exercise. Your doctor might tell you that either of those treatments will give you a 60 percent chance of getting better and a 20 percent chance of recovering outright.
Problem is, the study was bad science. Patients and independent scientists collaborated to analyze it and posted their findings Wednesday on Virology Blog, a site hosted by Columbia microbiology professor Vincent Racaniello.
And your chances of recovery? It was a battle that, until a year ago, seemed nearly hopeless. But patients like me were immediately skeptical, because the results contradicted the fundamental experience of our illness: Start low, build slowly but steadily, and get professional guidance, they advised.
The psychotherapy claim also made me skeptical. Instead, the therapist advises, patients need only to become more active and ignore their symptoms to fully recover.
In other words, while the illness might have been triggered by a virus or other physiological stressor, the problem was pretty much all in our heads. When a crunch, chew, or a sniffle triggers hot rage By contrast, in the American research community, no serious researchers were expressing doubts about the organic basis for the illness.
I knew that the right forms of psychotherapy and careful exercise could help patients cope, and I would have been thrilled if they could have cured me. I respect and value science. So the PACE trial left me befuddled: So I and many other patients dug into the science.
And almost immediately we saw enormous problems. To be considered recovered, participants had to meet established thresholds on self-assessments of fatigue and physical function, and they had to say they felt much better overall.
But after the unblinded trial started, the researchers weakened all these standards, by a lot.
In addition, the only evidence the researchers had that patients felt better was that patients said so. They found no significant improvement on any of their objective measures, such as how many patients got back to work, how many got off welfare, or their level of fitness.
But the subjective reports from patients seemed suspect to me. I imagined myself as a participant: Many patients worked to bring these flaws to light: They wrote blogs; they contacted the press; they successfully submitted carefully argued letters and commentaries to leading medical journals.
They even published papers in peer-reviewed scientific journals. They also filed Freedom of Information Act requests to gain access to the trial data from Queen Mary University of London, the university where the lead researcher worked.
While grieving for my fellow patients, I seethed at both the scientists and the journalists who refused to examine the trial closely. I could only hope that, eventually, PACE would drown under a slowly rising tide of good scienceeven if the scientific community never recognized its enormous problems.
To keep science honest, study data must be shared Then last October, David Tuller, a lecturer in public health and journalism at the University of California, Berkeley, wrote in Virology Blog a devastating expose of the scientific flaws of the trial.
Tuller described all the problems I had seen, along with several more. The project was a remarkable act of public service: And, at last, the criticisms gained traction. In the meantime, a Freedom of Information Act request from Australian patient Alem Matthees was making its way through the legal system.
It again cited the death threats. Startling results from a re-analysis Just before releasing the data,Queen Mary University of London did its own re-analysis on the question of how many patients got better, at least a little bit.HOTLINKS: MISCELLANEOUS SCIENCE FICTION/FANTASY/HORROR FILMS My Competitors: other websites of film lists X-Rated Sci-Fi/Fantasy Videos Sci-Fi Attacks on Los Angeles See also TIME TRAVEL: MOVIES AND TV-MOVIES ABOUT TIME TRAVEL OR TIME-LOOPS, below.
A science presenter, writer, speaker & former TV host; author of The Skeptic's Handbook (over , copies distributed & available in 15 languages). Two high school nerds attempt to create the perfect woman, but she turns out to be more than that.
A science presenter, writer, speaker & former TV host; author of The Skeptic's Handbook (over , copies distributed & available in 15 languages).
The Big Bang Theory (TV Series –) cast and crew credits, including actors, actresses, directors, writers and more. Science fiction (often shortened to Sci-Fi or SF) is a genre of speculative fiction, typically dealing with imaginative concepts such as advanced science and technology, spaceflight, time travel, and extraterrestrial ashio-midori.come fiction often explores the potential consequences of scientific and other innovations, and has been called a "literature of ideas".